Our Mission is to understand the causes and mechanisms of serious mental illness and to develop transformative treatments.

We study the molecular and neurobiological mechanisms of schizophrenia, bipolar disorder and other brain disorders. Based on human genetics findings at the Stanley Center for Psychiatric Research, we investigate how genetic alterations affect molecular, cellular, and circuit functions in the brain using genetically valid animal models. Using multidisciplinary approaches such as transcriptomics, proteomics, electrophysiology, scalp EEG, brain imaging and behavior, and aided by computational science, we seek to understand underlying causes and biological mechanisms of disease. Substantial effort is also placed on identifying potential therapeutic targets that could be translated into innovative therapeutics, and on using genetic animal models for testing of therapeutic agents and discovery of disease biomarkers that could be useful in clinical settings.